Ethnopharmacological relevance: Ghavoot is an Iranian traditional crude drug which is composed of different plant seeds in combination. This preparation has different traditional uses such as analgesic, anti inflammatory, adaptogen, general tonic, which has never been studied scientifically. In the present work the antinociceptive effect of Ghavoot has been studied in mice using three complementary methods. Materials and Methods: Antinociception was studied using tail flick, hot plate and formalin tests in mice. The animals received the Ghavoot for 14 days at doses of 12, 18 and 24g/kg orally. The antinociception effect of test groups was compared to ibuprofen. Results: The results showed that the doses of 18 and 24g/kg of Ghavoot exhibited dose dependent antinociception effect through hot plate and formalin tests which was significantly different from control group (p<0.05), but not in tail flick method. These results proposed both peripherally and centrally antinociception mechanisms for Ghavoot. Conclusion: The results here provide scientific evidence that Ghavoot has potential antinociception effects in mice.
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